Mathematics includes the study of such topics as quantity (number theory), structure (algebra), space (geometry) and change (analysis). It has no generally accepted definition. Mathematicians seek and use patterns to formulate new conjectures; they resolve the truth or falsity of such by mathematical proof. When mathematical structures are good models of real phenomena, mathematical reasoning can be used to provide insight or predictions about nature. Through the use of abstraction and logic, mathematics developed from counting, calculation, measurement, and the systematic study of the shapes and motions of physical objects. Practical mathematics has been a human activity from as far back as written records exist. The research required to solve mathematical problems can take years or even centuries of sustained inquiry. Mathematics is essential in many fields, including natural science, engineering, medicine, finance, and the social sciences. Applied mathematics has led to entirely new mathematical disciplines, such as statistics and game theory. Mathematicians engage in pure mathematics (mathematics for its own sake) without having any application in mind, but practical applications for what began as pure mathematics are often discovered later.